Material Safety Data Sheet: 2-Bromopropionic Acid
Identification
Product Name: 2-Bromopropionic Acid
Synonyms: Alpha-Bromopropionic Acid, Propanoic acid, 2-bromo-
CAS Number: 598-72-1
EC Number: 209-948-6
Molecular Formula: C3H5BrO2
Molecular Weight: 152.98 g/mol
Recommended Use: Chemical intermediate, laboratory reagent
Supplier Details: Contact chemical manufacturer or distributor for detailed information and support
Emergency Contact: Refer to local emergency numbers and poison control center for chemical exposure emergencies
Hazard Identification
GHS Classification: Acute Toxicity Oral (Category 3), Skin Corrosion/Irritation (Category 2), Serious Eye Damage/Irritation (Category 2A)
Signal Word: Danger
Hazard Statements: Toxic if swallowed; causes skin irritation; causes serious eye irritation
Pictograms: Skull and crossbones, exclamation mark, corrosion
Precautionary Statements: Wear protective gloves, eye protection, and face protection. Do not eat, drink, or smoke during use. Wash thoroughly after handling. Avoid breathing dust, fumes, mist, or vapors.
Potential Health Effects: Eyes: Causes irritation or possible burns. Skin: Causes irritation, redness, and pain. Inhalation: Harmful; may cause respiratory irritation, coughing, or shortness of breath. Ingestion: Toxic, may cause burning sensation, gastrointestinal distress, or systemic toxicity.
Composition / Information on Ingredients
Chemical Name: 2-Bromopropionic Acid
Percent Composition: ≥98%
CAS Number: 598-72-1
Impurities/Additives: Trace amounts of propionic acid, water
Hazardous Components: Contains brominated organic compound, all components classified as hazardous per OSHA 29 CFR 1910.1200
First Aid Measures
Inhalation: Move person to fresh air. Seek medical attention if symptoms persist. If not breathing, give artificial respiration and contact emergency services.
Skin Contact: Remove contaminated clothing. Rinse skin with water for at least 15 minutes. Get medical attention for visible irritation or persistent discomfort.
Eye Contact: Rinse cautiously with water for at least 15 minutes, lifting eyelids. Remove contact lenses if present and easy to do. Seek medical care immediately if irritation continues.
Ingestion: Do not induce vomiting. Rinse mouth with water. Seek prompt medical attention. Never give anything by mouth to an unconscious person.
Most Important Symptoms: Burning sensation, coughing, skin redness, swelling, gastrointestinal irritation
Advice for Physician: Provide symptomatic and supportive treatment; monitor vital signs.
Fire-Fighting Measures
Suitable Extinguishing Media: Water spray, carbon dioxide, alcohol-resistant foam, dry chemical powder
Unsuitable Extinguishing Media: Strong water jets
Hazardous Combustion Products: Releases hydrogen bromide, carbon oxides when burned
Special Firefighting Equipment: Wear self-contained breathing apparatus (SCBA) and complete protective gear
Precautions: Keep unnecessary personnel away from fire area. Move containers from fire area if possible and safe. Cool containers with water spray.
Accidental Release Measures
Personal Precautions: Use personal protective equipment. Ensure adequate ventilation. Avoid contact with eyes and skin.
Environmental Precautions: Prevent chemical runoff to drains, watercourses, and soil.
Spill Containment: Isolate area and ventilate. Absorb with inert absorbent material (sand, earth). Place in proper waste container for disposal.
Cleanup Procedures: Collect spilled material with non-sparking tools and dispose of according to regulations. Wash spill area thoroughly after clean-up.
Handling and Storage
Handling Practices: Wear protective clothing and gloves. Use in a fume hood or well-ventilated area. Avoid ingestion, inhalation, and contact with skin or eyes.
Storage Conditions: Store in tightly closed container. Keep away from heat, moisture, and incompatible substances including oxidizers, bases, and metals. Store in a cool, dry, and well-ventilated place.
Incompatibilities: Strong bases, strong oxidizing agents, reducing agents, metals
Other Precautions: Use dedicated storage area and restrict access to trained personnel.
Exposure Controls and Personal Protection
Occupational Exposure Limits: No OSHA PEL or ACGIH TLV specifically listed for 2-bromopropionic acid.
Engineering Controls: Work with chemical fume hood. Use local exhaust to remove vapors and mists.
Personal Protection: Nitrile or neoprene gloves, splash-proof chemical goggles, face shield, lab coat, respirator if ventilation is inadequate
Hygiene Practices: Wash hands after handling chemical and before eating or drinking. Avoid wearing contact lenses when handling chemicals.
Physical and Chemical Properties
Appearance: Colorless to pale yellow liquid or crystalline solid
Odor: Penetrating, pungent
Odor Threshold: Not available
pH (1% solution): Acidic
Melting Point: 23-25°C
Boiling Point: 184-186°C
Flash Point: 91°C (closed cup)
Evaporation Rate: Not established
Flammability: Not flammable under normal conditions
Vapor Pressure: Low at room temperature
Vapor Density: Heavier than air
Specific Gravity/Density: 1.69 (at 20°C)
Solubility in Water: Soluble
Partition Coefficient: log Kow ~0.8 (estimated)
Auto-Ignition Temperature: Not available
Decomposition Temperature: Not specified
Stability and Reactivity
Stability: Stable under recommended storage conditions
Reactivity: Reacts vigorously with strong bases, acids, oxidizers, certain metals
Possible Hazardous Reactions: May produce toxic hydrogen bromide fumes on thermal decomposition or contact with acids
Conditions to Avoid: Moisture, heat, flames, incompatible materials
Hazardous Decomposition Products: Hydrogen bromide, carbon oxides
Polymerization: Not reported under normal conditions
Toxicological Information
Routes of Exposure: Inhalation, skin absorption, ingestion, eye contact
Acute Toxicity - Oral (LD50 Rat): ~70 mg/kg
Acute Toxicity - Dermal (LD50): Data not available
Acute Toxicity - Inhalation (LC50): Data not available
Skin Corrosion/Irritation: Causes significant skin irritation
Serious Eye Damage/Irritation: Causes serious irritation and possible chemical burns
Respiratory Sensitization: Data unavailable
Germ Cell Mutagenicity: No data available
Carcinogenicity: Not classified as carcinogenic by NTP, IARC, or OSHA
Reproductive Toxicity: No data available
STOT - Single Exposure: Respiratory system irritation
STOT - Repeated Exposure: No data available
Aspiration Hazard: Not classified
Symptoms: Skin and mucous membrane burns, gastrointestinal upset, respiratory distress
Ecological Information
Ecotoxicity: Harmful to aquatic organisms with short-term exposure
Persistence and Degradability: Limited degradation under typical environmental conditions
Bioaccumulative Potential: Low based on estimated log Kow
Mobility in Soil: Expected to be mobile due to water solubility
Other Adverse Effects: No significant ozone-depleting properties established.
Disposal Considerations
Waste Disposal Methods: Dispose as hazardous chemical waste according to local, regional, and national regulations.
Contaminated Packaging: Rinse containers thoroughly, puncture, and dispose at certified chemical waste facility.
Special Instructions: Avoid discharge into drains, watercourses, and environment. Label waste containers clearly.
Transport Information
UN Number: 3265
Proper Shipping Name: Corrosive liquid, acidic, organic, n.o.s. (2-Bromopropionic Acid)
Transport Hazard Class: 8 (Corrosive)
Packing Group: II
Marine Pollutant: Not classified
Special Precautions: Handle and transport in upright containers, avoid excessive heat, comply with local and international transport regulations
Regulatory Information
US Federal Regulations: TSCA-listed; SARA Title III Sec. 302/304/311/312 - Acute health hazard
OSHA Status: Hazardous by definition of Hazard Communication Standard
Canada WHMIS: D1B (Toxic), E (Corrosive)
EU Classification: Xi (Irritant), T (Toxic)
Labeling: GHS-compliant hazard labels and safety data sheet required
Other State/Federal Regulations: Refer to state and international requirements, including REACH, DSL, and chemical inventories.
