Material Safety Data Sheet (MSDS) for Tert-Butyl 2-Bromo Isobutyrate

1. Identification

Product Name: Tert-Butyl 2-Bromo Isobutyrate
Chemical Synonyms: 2-Bromo-2-methylpropanoic acid tert-butyl ester
Recommended Use: Laboratory chemicals, chemical synthesis
Manufacturer: Contact the chemical supplier for specific manufacturer information
Emergency Contact: Local emergency line or national poison control center
Date of Preparation: Refer to label or supplier documentation
CAS Number: 50818-60-3
Supplier Information: Available through safety documentation or chemical supplier’s website

2. Hazard Identification

Classification: Acute toxicity (oral, dermal, inhalation), skin and eye irritation
Hazard Symbols: Corrosive, harmful
Signal Word: Warning
Hazard Statements: Causes skin and eye irritation, may cause respiratory irritation, harmful if swallowed, toxic to aquatic life
Precautionary Statements: Avoid breathing dust, vapors or spray. Wear protective gloves, clothing, eye and face protection. Do not eat, drink or smoke while handling the substance.

3. Composition / Information on Ingredients

Chemical Identity: Tert-Butyl 2-Bromo Isobutyrate
CAS Number: 50818-60-3
Purity: Greater than 95% (contact supplier for lot specifications)
Impurities: Minor organic impurities possible
Molecular Formula: C7H13BrO2
Molecular Weight: 209.08 g/mol

4. First Aid Measures

Inhalation: Move affected person into fresh air, keep at rest, seek medical attention if symptoms persist
Skin Contact: Remove contaminated clothing, wash affected area with plenty of water and soap, seek medical advice if irritation develops
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses, continue rinsing, consult an ophthalmologist if discomfort continues
Ingestion: Rinse mouth thoroughly with water, do not induce vomiting, seek immediate medical advice
Most Important Symptoms: Irritation, burning sensation on skin and eyes, cough, dizziness, nausea (for large exposures)

5. Fire-Fighting Measures

Suitable Extinguishing Media: Carbon dioxide, dry chemical powder, foam, water spray
Unsuitable Extinguishing Media: Avoid direct stream of water in case of chemical fire
Specific Hazards: May give off toxic and corrosive vapors including hydrogen bromide and carbon oxides when burning; containers may rupture in heat
Protective Equipment for Firefighters: Use self-contained breathing apparatus and full protective gear
Special Precautions: Move containers from fire area if possible without risk, dike water runoff to prevent environmental contamination

6. Accidental Release Measures

Personal Precautions: Evacuate unnecessary personnel, provide proper ventilation, wear chemical-resistant gloves and goggles, avoid breathing vapors or dust
Environmental Precautions: Prevent further leakage, spillage or entry into drains, surface and groundwater
Methods for Cleanup: Contain spill using inert absorbent material, collect in comfortable chemical waste container, ventilate contaminated area, wash site after material pickup
Additional Guidance: Dispose of contaminated cleanup materials according to local regulations, decontaminate protective gear before reuse

7. Handling and Storage

Precautions for Safe Handling: Handle in a chemical fume hood, avoid inhalation of vapors, dusts or mists, minimize contact with skin or eyes, clean up spills promptly
Advice for Safe Storage: Store in tightly sealed original container, keep in a cool, dry, well-ventilated place, protect from direct sunlight, heat sources, moisture, incompatible materials, keep away from oxidizers and acids
Incompatibilities: Strong bases, strong oxidizers, acids
Hygiene Practices: Wash hands thoroughly after handling, do not eat or drink in the laboratory, keep work area clean

8. Exposure Controls and Personal Protection

Exposure Limits: No specific occupational exposure limits set, keep exposure as low as reasonably achievable
Engineering Controls: Use mechanical exhaust or laboratory hood, maintain eyewash stations and safety showers
Personal Protective Equipment: Wear resistant gloves (nitrile or neoprene), safety goggles or face shield, lab coat, mask or respirator if engineering controls are inadequate
Respiratory Protection: Use NIOSH-approved respirator if exposure risk exists, especially in poor ventilation
Environmental Controls: Follow local regulations to prevent pollution and runoff

9. Physical and Chemical Properties

Appearance: Colorless to pale yellow liquid
Odor: Sharp, characteristic
pH: Not applicable
Melting Point/Freezing Point: Typically -13°C
Boiling Point: 140–144°C at 760 mmHg
Flash Point: 80°C
Evaporation Rate: No data available
Flammability: Not easily combustible but can burn
Vapor Pressure: 2.6 mmHg at 25°C
Vapor Density: Heavier than air
Relative Density: 1.19 g/cm³
Solubility: Insoluble in water, miscible in organic solvents like dichloromethane and ether
Partition Coefficient (n-octanol/water): Approx. 1.8
Viscosity: Not determined

10. Stability and Reactivity

Chemical Stability: Stable under recommended handling and storage conditions
Conditions to Avoid: Exposure to moisture, heat, flames, strong light
Incompatible Materials: Strong oxidizers, strong bases, acids
Hazardous Decomposition Products: Hydrogen bromide gas, carbon monoxide, carbon dioxide
Reactivity: Sensitive to strong acids and bases, may decompose on prolonged or excessive heating

11. Toxicological Information

Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Acute Toxicity: Harmful if swallowed; estimated oral LD50 (rat): not published, avoid all routes of exposure
Chronic Effects: Prolonged contact may cause dermatitis or conjunctival irritation; no proven carcinogenic, mutagenic, or reproductive toxicity based on current data
Symptoms: Coughing, nausea, dizziness, headache, skin and eye irritation
Sensitization: Not a known skin sensitizer based on available data
Target Organs: Mucous membranes, skin, eyes, respiratory system

12. Ecological Information

Ecotoxicity: Harmful to aquatic organisms, risk of long-term adverse effects in aquatic environment
Persistence and Degradability: Contains organic brominated compound, biodegradation is slow, chemical may persist
Bioaccumulative Potential: Possible moderate potential for bioaccumulation
Mobility in Soil: Low water solubility, can leach into groundwater over time
Other Adverse Effects: Avoid release to environment, collect spillage and dispose with care

13. Disposal Considerations

Waste Treatment Methods: Dispose as hazardous chemical waste, use local licensed disposal facility, follow regional, national, and international regulations
Recommended Disposal Containers: Use sealed, chemically resistant containers clearly labeled
Instructions for Disposal: Do not pour down drains, avoid contamination of soil and water, all contaminated materials must go through a chemical waste route
Special Precautions: Contact authorized waste company, keep detailed disposal records

14. Transport Information

UN Number: UN 3265
Proper Shipping Name: Corrosive liquid, organic, n.o.s. (Tert-Butyl 2-Bromo Isobutyrate)
Hazard Class: 8 (Corrosive substances)
Packing Group: III
Labels Required: Corrosive label, keep upright during transport, avoid movement or impact
Special Transport Note: Protect shipment from physical damage, keep container securely closed
Marine Pollutant: Not specifically classified but minimize accidental release to surface waters

15. Regulatory Information

Safety, Health and Environmental Regulations: Subject to workplace safety and hazardous substances regulations based on location
OSHA: Handle as hazardous chemical under OSHA Hazard Communication Standard in the United States
TSCA Status: Not listed specifically; follow chemical inventory reporting standards
EU Regulation: Requires REACH pre-registration or notification
WHMIS (Canada): Classified as hazardous, consult provincial regulations
Other Regulatory Lists: Chemical may appear on national inventories or be restricted; verify with local chemical authority
Labeling: Clear, accurate, include hazard symbols and risk statements